![]() ![]() Carnosol also inhibited LPS-induced p38 and p44/42 mitogen-activated protein kinase (MAPK) activation at a higher concentration (20 μM). These activities were referred to down-regulation of inhibitor κB (IκB) kinase (IKK) activity by carnosol (5 μM), thus inhibited LPS-induced phosphorylation as well as degradation of IκBα. Carnosol also showed inhibition of iNOS and NF-κB promoter activity in transient transfection assay. Carnosol treatment showed reduction of nuclear factor-κB (NF-κB) subunits translocation and NF-κB DNA binding activity in activated macrophages. Western blot, reverse transcription–polymerase chain reaction, and northern blot analyses demonstrated that carnosol decreased LPS-induced iNOS mRNA and protein expression. Treatment of mouse macrophage RAW 264.7 cell line with carnosol markly reduced lipopolysaccharide (LPS)-stimulated NO production in a concentration-related manner with an IC 50 of 9.4 μM but other tested compounds had slight effects. High concentrations of nitric oxide (NO) are produced by inducible NO synthase (iNOS) in inflammation and multiple stages of carcinogenesis. Carnosol showed potent antioxidative activity in α,α-diphenyl-β-picrylhydrazyl (DPPH) free radicals scavenge and DNA protection from Fenton reaction. In the present study, we compared the antioxidant activity of carnosol and other compounds extracted from rosemary. Carnosol functions as antioxidant and anticarcinogen. 2008 27:1085–9.Carnosol is a naturally occurring phytopolyphenol found in rosemary. ![]() ABO-incompatible heart transplantation in infants: analysis of the United Network for Organ Sharing Database. Hageman M, Michaud N, Chinnappan I, et al. ![]() Equivalent outcomes for pediatric heart transplantation recipients: ABO-blood group incompatible versus ABO-compatible. 2012 31:791–6.ĭipchand AI, Pollock BarZiv SM, Manlhoit C, et al. Pushing the boundaries: the current status of ABO-incompatible cardiac transplantation. ABO-incompatible heart transplantation in infants. West LJ, Pollock-Barziv SM, Dipchand AI, et al. ABO-incompatible heart transplantation: a perfusion strategy. Multicenter experience of ABO-incompatible pediatric cardiac transplantation. Acute antibody-mediated rejection in living ABO-incompatible kidney transplantation: long-term impact and risk factors. Changes of circulating antibody levels induced by ABO antibody adsorption for ABO-incompatible kidney transplantation. Impact of TGF beta1 gene polymorphisms on acute and chronic rejection in pediatric heart transplant allografts. Identification of gene markers for the prediction of allograft rejection or permanent acceptance. ![]() Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Phosphorylated S6 ribosomal Protein a novel biomarker of antibody-mediated rejection in heart allografts. Chronic cardiac transplant arteriopathy in mice: relationship of alloantibody, C 4d deposition and neointimal fibrosis. Humoral heart rejection (severe allograft dysfunction with no signs of cellular rejection or ischemia) : incidence, management, and the value of C4d for diagnosis. 2005 18:303–8.Ĭrespo-Leiro MG, Veiga-Barreiro A, Dompenech N, et al. Abnormal total ejection isovolume index as early noninvasive marker of chronic rejection in heart transplantation. The potential clinical role of ultrasonic strain and strain rate imaging in diagnosing acute rejection after heart transplantation. Marciniak A, Eroglu E, Marciniak M, et al. Cardiac allograft vasculopathy: pathology, prevention and treatment. Real-time sonography in central venous access for endomyocardial biopsy in cardiac transplantation patients. ![]()
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